Annotated Bibliography Programmed Cell Death - 2069 Words

By utilizing these two transgene expressions in a synchronized way, the adenovirus is granted the ability to replicate, specifically when it is within a tumor cell. The promoter hTERT controls the specificity of E1a’s ability for viral replication. This assures that the adenovirus only replicates within cancer cells because the gene marker is only triggered where the hTERT expression is prevalent, which, as indicated earlier, is only within cancerous cells. Another impressive dimension that adds to the efficacy of Ad-Apoptin-hTERT-E1a is the adenoviruses’ ability to attack tumor cells through the addition of the therapeutic transgene expression Apoptin. Apoptin is a protein that is known to induce the process of apoptosis specifically within malignant cells, but not in regular cells [3]. Apoptosis is often called â€Å"programmed cell death† because it is a process in which cells that are no longer needed within an organism are recognized and then destroyed. Inserting this transgene expression into the genome of Ad-Apoptin-hTERT-E1a creates a cancer specific adenovirus equipped with dual threat potential. With these transgene expressions inserted into the genome of an adenovirus, Ad-Apoptin-hTERT-E1a, is a genetically modified oncolytic adenovirus that has been created which can theoretically eradicate cancer cells through both lysis and apoptosis, but not negatively effect normal cells within the host. 4. Case Study: Clinical Analysis of Oncolytic Adenovirus A study byShow MoreRelatedNanomedicine: A Tiny World Essay2111 Words   |  9 Pages (Appendix 1, Figure 4 and 5) These medical robots can be imagined to be made from magnetic carriers and flagellated bacteria controlled by a computer. Before they are placed in our body, they are programmed with a set of instructions so they can differentiate their target from healthy organs or cells. Martel believes that once the nanobots are made, they will have a big impact on curing cancer by delivering them directly to the tumour through the bloodstream. Metin Sitti, director of the nanoroboticsRead MoreIs Technology Really Making Life Easier?5158 Words   |  21 Pagesreally making life easier? I took the stance that advancement in technology has led to major sociological issues that are currently being felt and will be felt for generations to come. I highlighted the creation of such devices and services such as cell phones, computers, the internet, and social media. My research has only show n more support to what I had believed prior to starting this process. My conclusion based off the information to follow is that technology may have made our lives more convenientRead MoreQuality Improvement328284 Words   |  1314 Pagesthe field. It is available at www.wiley.com/college/montgomery. Student Resource Manual The text contains answers to most of the odd-numbered exercises. A Student Resource Manual is available from John Wiley Sons that presents comprehensive annotated solutions to these same odd-numbered problems. This is an excellent study aid that many text users will find extremely helpful. The Student Resource Manual may be ordered in a set with the text or purchased separately. Contact your local Wiley representativeRead MoreLibrary Management204752 Words   |  820 Pagesmanagers do in the for-profit and the not-for-profit spheres is the same. The well-known management expert Peter Managing in Today’s Libraries and Information Centers    1 Drucker turned his attention to the nonprofit world a few years before his death. He stressed the similarities between for-profit and nonprofit organizations. He advocated the need for not-for-profit organizations to focus on mission, demonstrate accountability, and achieve results.12 Drucker suggested that the managers in every